Name: Δ12-Prostaglandin D2
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HIT ID:HIT218638201
Cas No:
Common Name:Δ12-Prostaglandin D2
alias:Δ12-PGD2
IUPAC:7-[5-hydroxy-2-(3-hydroxyoctylidene)-3-oxocyclopentyl]hept-5-enoic acid
IUPAC:7-[5-hydroxy-2-(3-hydroxyoctylidene)-3-oxocyclopentyl]hept-5-enoic acid
InChI key:OBTVQKDILGZFPY-UHFFFAOYSA-N

Molecular Formula:C20H32O5
Molecular Weight:352.471
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCC(O)CC=C1C(CC=CCCCC(O)=O)C(O)CC1=O
SMILES:CCCCCC(O)CC=C1C(CC=CCCCC(O)=O)C(O)CC1=O

Prostaglandin D2 (PGD2) is a primary enzymatic prostaglandin derived from PGH2 and is abundantly produced in the cerebrospinal fluid (CSF) by the lipocalin-type PGD synthase, and peripherally by myeloid cells such as mast cells and basophils via a hematopoietic-type PGD synthase. PGD2 is chemically unstable and presents challenges for use and analysis due to its brief in vivo half-life. Δ12-PGD2, an initial decomposition product of PGD2, acts as an intermediate in the pathway to Δ12-PGJ2, a cyclopentenone prostaglandin known for its antimitotic and carcinogenic properties. The metabolism of Δ12-PGD2 involves the addition of thiol nucleophiles, a common pathway for many cyclopentenone prostaglandins.

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