Name: MNI-caged-L-glutamate TFA
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HIT ID:HIT218638460
Cas No:
Common Name:MNI-caged-L-glutamate TFA
IUPAC:(2S)-2-amino-5-(4-methoxy-7-nitro-2,3-dihydro-1H-indol-1-yl)-5-oxopentanoic acid; trifluoroacetic acid
IUPAC:(2S)-2-amino-5-(4-methoxy-7-nitro-2,3-dihydro-1H-indol-1-yl)-5-oxopentanoic acid; trifluoroacetic acid
InChIKey:YHZQLUFSVKYSRH-FVGYRXGTSA-N

Molecular Formula:C16H18F3N3O8
Molecular Weight:437.328
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.COc1ccc(c2N(CCc12)C(=O)CC[C@H](N)C(O)=O)N(=O)=O
SMILES:OC(=O)C(F)(F)F.COc1ccc(c2N(CCc12)C(=O)CC[C@H](N)C(O)=O)N(=O)=O

MNI-caged-L-glutamate, a derivative of glutamate conjugated with a 4-methoxy-7-nitroindolinyl (MNI) photoprotective group, remains pharmacologically inactive at neuronal glutamate receptors at concentrations up to mM. Upon light exposure (300 - 380 nm excitation), it rapidly releases L-glutamate by cleaving the MNI group within submicroseconds. This characteristic enables the investigation of fast synaptic glutamate receptor mechanisms in situ.

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