Name: PAOPA
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HIT ID:HIT218639023
Cas No:114200-31-6
Common Name:PAOPA
IUPAC:(2S)-N-[(3R)-1-(carbamoylmethyl)-2-oxopyrrolidin-3-yl]pyrrolidine-2-carboxamide
IUPAC:(2S)-N-[(3R)-1-(carbamoylmethyl)-2-oxopyrrolidin-3-yl]pyrrolidine-2-carboxamide
InChI key:QXHVGEXNEZRSGG-JGVFFNPUSA-N

Molecular Formula:C11H18N4O3
Molecular Weight:254.29
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:NC(=O)CN1CC[C@@H](NC(=O)[C@@H]2CCCN2)C1=O
SMILES:NC(=O)CN1CC[C@@H](NC(=O)[C@@H]2CCCN2)C1=O

PAOPA belongs to natural product derivatives and serves as an allosteric modulator of the dopamine D2 receptor, possessing the characteristic of promoting binding between high-affinity D2 receptors and agonists. This compound finds application in preclinical studies for schizophrenia and extrapyramidal dysfunction, effectively alleviating behavioral and biochemical abnormalities in rodent models.

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