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HIT218640051
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HIT218640051
  • HIT ID:HIT218640051
  • Cas No:13539-26-9
  • Common Name:6-Hydroxygenistein
  • IUPAC:5,6,7-trihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
    IUPAC:5,6,7-trihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
  • InChIKey:HDXSEWOOSVMREY-UHFFFAOYSA-N
  • Molecular Formula:C15H10O6
  • Molecular Weight:286.239
  • Hydrogen Bond Donor (HBD):
  • Hydrogen Bond Acceptor (HBA):
  • LogP:
  • SMILES:Oc1ccc(cc1)-c1coc2cc(O)c(O)c(O)c2c1=O
    SMILES:Oc1ccc(cc1)-c1coc2cc(O)c(O)c(O)c2c1=O
  • 6-Hydroxygenistein is a naturally occurring hydroxylated isoflavone known for its potent antioxidant and anti-hypoxia properties. In DPPH radical scavenging assays, it achieves an 86.94% removal rate at 4 mmol/L, outperforming the standard positive control rutin. Research applications focus on its ability to protect against hypoxia-induced cellular damage by activating the Nrf2/HO-1 and PI3K/AKT signaling pathways while suppressing oxidative stress and inflammatory responses. This compound is widely used in cell-based and in vivo studies investigating mechanisms of hypoxic injury and neuroprotection.
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