Name: Isoreserpiline
Rating: 5 (10 reviews)

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HIT ID:HIT218645516
Cas No:
常用名:Isoreserpiline
别名:3-Isoreserpilinic Acid, methyl ester
IUPAC:methyl 6,7-dimethoxy-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate
IUPAC:methyl 6,7-dimethoxy-16-methyl-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,10}.0^{4,9}.0^{15,20}]henicosa-2(10),4,6,8,18-pentaene-19-carboxylate
InChI key:FGWJRZQNNZVCHR-UHFFFAOYSA-N

分子式:C23H28N2O5
分子量:412.486
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC(=O)C1=COC(C)C2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12
SMILES:COC(=O)C1=COC(C)C2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12

Isoreserpiline, an indole alkaloid discovered in R. tetraphylla, exhibits a range of biological activities. This compound enhances the antibacterial efficacy of nalidixic acid against both nalidixic acid-sensitive and -resistant E. coli strains through a synergistic effect. Additionally, at a dosage of 25 mg/kg, it mitigates amphetamine-induced hyperactivity in mice.

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