Name: PF-05661014
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HIT ID:HIT218657111
Cas No:2153474-85-0
Common Name:PF-05661014
IUPAC:1-benzyl-3-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}urea
IUPAC:1-benzyl-3-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}urea
InChI key:BMCSKUJQKUYLNE-UHFFFAOYSA-N

Molecular Formula:C17H16N4O3S2
Molecular Weight:388.46
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:O=C(NCc1ccccc1)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1
SMILES:O=C(NCc1ccccc1)Nc1ccc(cc1)S(=O)(=O)Nc1nccs1

PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.

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