Name: 13-POHSA
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HIT ID:HIT218657238
Cas No:
Common Name:13-POHSA
IUPAC:13-(hexadec-9-enoyloxy)octadecanoic acid
IUPAC:13-(hexadec-9-enoyloxy)octadecanoic acid
InChIKey:FHXCZZFHUCAQAA-UHFFFAOYSA-N

Molecular Formula:C34H64O4
Molecular Weight:536.882
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCCC=CCCCCCCCC(=O)OC(CCCCC)CCCCCCCCCCCC(O)=O
SMILES:CCCCCCC=CCCCCCCCC(=O)OC(CCCCC)CCCCCCCCCCCC(O)=O

13-POHSA (palmitoleic acid esterified to 13-hydroxy stearic acid) is a type of branched fatty acid esters of hydroxy fatty acids (FAHFAs), which have recently been discovered as endogenous lipids whose levels are modulated by fasting and high-fat diets, and are linked to insulin sensitivity in mice. Notably, the concentration of 13-POHSA in the serum significantly increases in glucose tolerant AG4OX mice, a model that overexpresses the Glut4 glucose transporter in adipose tissue, suggesting its physiological relevance. Like other FAHFAs, 13-POHSA is believed to enhance glucose tolerance, promote insulin secretion, and exert anti-inflammatory properties, highlighting its potential importance in managing metabolic syndrome and inflammation.

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