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  3. HIT218657268
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HIT218657268
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HIT218657268
  • HIT ID:HIT218657268
  • Cas No:
  • 常用名:NBD-FTY720 phenoxy hydrochloride
    常用名:NBD-FTY720 phenoxy hydrochloride
  • IUPAC:2-amino-2-{2-[4-({6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexyl}oxy)phenyl]ethyl}propane-1,3-diol hydrochloride
    IUPAC:2-amino-2-{2-[4-({6-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]hexyl}oxy)phenyl]ethyl}propane-1,3-diol hydrochloride
  • InChI key:HYXNNTOWDYHBFK-UHFFFAOYSA-N
  • 分子式:C23H32ClN5O6
  • 分子量:509.99
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Cl.NC(CO)(CO)CCc1ccc(OCCCCCCNc2ccc(c3nonc23)N(=O)=O)cc1
    SMILES:Cl.NC(CO)(CO)CCc1ccc(OCCCCCCNc2ccc(c3nonc23)N(=O)=O)cc1
  • FTY720, an immune modulator, down-regulates sphingosine-1-phosphate (S1P) receptors, enhances the activity of sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1, and inhibits cytosolic phospholipase A2 activity. Its efficacy relies on in vivo phosphorylation by sphingosine kinases, resulting in FTY720-phosphate which also down-regulates S1P receptors. NBD-FTY720, a fluorescently-labeled analog of FTY720, retains the hydroxy methyl side chain targeted for phosphorylation, suggesting potential phosphorylation in vivo.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 4,200.00
    1

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