Name: (+)-ITD-1
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

* 凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

HIT ID:HIT218658689
Cas No:1409968-46-2
Common Name:(+)-ITD-1
IUPAC:ethyl (4R)-4-{[1,1'-biphenyl]-4-yl}-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
IUPAC:ethyl (4R)-4-{[1,1'-biphenyl]-4-yl}-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
InChI key:ULFUJLFTRWWLPO-DEOSSOPVSA-N

Molecular Formula:C27H29NO3
Molecular Weight:415.533
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCOC(=O)C1=C(C)NC2=C([C@H]1c1ccc(cc1)-c1ccccc1)C(=O)CC(C)(C)C2
SMILES:CCOC(=O)C1=C(C)NC2=C([C@H]1c1ccc(cc1)-c1ccccc1)C(=O)CC(C)(C)C2

(+)-ITD-1 is an inhibitor of TGF-β, effectively inhibiting TGF-β2 with an IC50 of 0.46 μM. It promotes the degradation of the TGF-β type II receptor (TGFBR2) and the differentiation of cardiomyocytes. Additionally, it suppresses the formation of the mesoderm during the early differentiation of mouse embryonic stem cells (mESCs).

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~