Name: 15(R)-15-methyl Prostaglandin F2α
Rating: 5 (10 reviews)

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HIT ID:HIT218659462
Cas No:
常用名:15(R)-15-methyl Prostaglandin F2α
常用名:15(R)-15-methyl Prostaglandin F2α
别名:15(R)-15-methyl PGF2α
IUPAC:7-[3,5-dihydroxy-2-(3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl]hept-5-enoic acid
IUPAC:7-[3,5-dihydroxy-2-(3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl]hept-5-enoic acid
InChI key:DLJKPYFALUEJCK-UHFFFAOYSA-N

分子式:C21H36O5
分子量:368.514
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC(C)(O)C=CC1C(O)CC(O)C1CC=CCCCC(O)=O
SMILES:CCCCCC(C)(O)C=CC1C(O)CC(O)C1CC=CCCCC(O)=O

15(R)-15-methyl PGF2α, a metabolically stable analog of PGF2α, is an inactive, prodrug PGF agonist intended for activation by gastric acid through oral administration. This transformation involves acid-catalyzed epimerization that converts 15(R)-15-methyl PGF2α into its active counterpart, the 15(S)-isomer. Upon conversion, the 15(S)-isomer has been shown to induce luteolysis in rhesus monkeys following an approximately 12 mg/animal dosage, a response not observed with the 15(R)-isomer.

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