Name: ZJT1 2HCl
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HIT ID:HIT218667144
Cas No:2758431-94-4
Common Name:ZJT1 2HCl
IUPAC:2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-{4-[(piperidin-4-yl)methyl]piperazin-1-yl}-2,3-dihydro-1H-isoindole-1,3-dione dihydrochloride
IUPAC:2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-{4-[(piperidin-4-yl)methyl]piperazin-1-yl}-2,3-dihydro-1H-isoindole-1,3-dione dihydrochloride
InChIKey:RPBQFDUBJGNGHE-UHFFFAOYSA-N

Molecular Formula:C23H30Cl2FN5O4
Molecular Weight:530.42
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cl.Cl.Fc1cc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2cc1N1CCN(CC2CCNCC2)CC1
SMILES:Cl.Cl.Fc1cc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c2cc1N1CCN(CC2CCNCC2)CC1

Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) serves as a cereblon-based E3 ubiquitin ligase ligand, utilizing Pomalidomide (CRBN) for cereblon protein recruitment. This compound can be conjugated with a protein ligand through a linker to create a PROTAC ^[1].

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