Name: α1A-AR Degrader 9c
Rating: 4 (6 reviews)

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HIT ID:HIT218667155
Cas No:2863635-02-1
Common Name:α1A-AR Degrader 9c
IUPAC:2-{2-[2-(2-{4-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethoxy}-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]acetamide
IUPAC:2-{2-[2-(2-{4-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazine-1-carbonyl]-1H-1,2,3-triazol-1-yl}ethoxy)ethoxy]ethoxy}-N-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]acetamide
InChIKey:SFODRSARUJDQSA-UHFFFAOYSA-N

Molecular Formula:C38H43N11O11
Molecular Weight:829.828
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1cn(CCOCCOCCOCC(=O)Nc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)nn1
SMILES:COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1cn(CCOCCOCCOCC(=O)Nc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)nn1

α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC₅₀ of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-proliferative effects against PC-3 cells, presenting an IC₅₀ value of 6.12 μM. This compound demonstrates antitumor activity and holds potential for prostate cancer research ^[1].

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