Name: TAPI 2
Rating: 5 (10 reviews)

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HIT ID:HIT218667172
Cas No:689284-12-6
常用名:TAPI 2
IUPAC:(2R)-N-[(1S)-1-{[(1S)-1-[(2-aminoethyl)carbamoyl]ethyl]carbamoyl}-2,2-dimethylpropyl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
IUPAC:(2R)-N-[(1S)-1-{[(1S)-1-[(2-aminoethyl)carbamoyl]ethyl]carbamoyl}-2,2-dimethylpropyl]-N'-hydroxy-2-(2-methylpropyl)butanediamide
InChI key:LMIQCBIEAHJAMZ-GZBFAFLISA-N

分子式:C19H37N5O5
分子量:415.535
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C
SMILES:CC(C)C[C@H](CC(=O)NO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)NCCN)C(C)(C)C

ADAM-17 (TACE) and MMP inhibitor (Ki = 120 nM at ADAM-17). Sensitizes cancer stem cells to the lethal effects of 5-FU in vitro. Blocks shedding of TNF-α from cell membranes.

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