Name: ACE-083
Rating: 4 (6 reviews)

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HIT ID:HIT218671624
Cas No:81080-10-6
Common Name:ACE-083
alias:ACE083, ACE 083
IUPAC:N-{4-hydroxy-3,5-bis[(piperidin-1-yl)methyl]phenyl}acetamide
IUPAC:N-{4-hydroxy-3,5-bis[(piperidin-1-yl)methyl]phenyl}acetamide
InChIKey:AVPLCNNLKMYJHF-UHFFFAOYSA-N

Molecular Formula:C20H31N3O2
Molecular Weight:345.487
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CC(=O)Nc1cc(CN2CCCCC2)c(O)c(CN2CCCCC2)c1
SMILES:CC(=O)Nc1cc(CN2CCCCC2)c(O)c(CN2CCCCC2)c1

ACE-083 is a follistatin-based therapeutic agent designed for localized activity that increases muscle mass by binding myostatin and related muscle-regulatory factors, and although ACE-083 demonstrated consistent muscle volume increases across multiple clinical trials, its lack of functional improvement in phase II facioscapulohumeral muscular dystrophy studies led to discontinuation of its development for FSHD.

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