Name: Nrf2-ARE/hMAO-B/QR2 modulator 1
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HIT ID:HIT218672593
Cas No:
Common Name:Nrf2-ARE/hMAO-B/QR2 modulator 1
IUPAC:5-[(1E)-2-(4-methoxyphenyl)ethenyl]-3-(prop-2-yn-1-yl)-2,3-dihydro-1,3,4-oxadiazol-2-one
IUPAC:5-[(1E)-2-(4-methoxyphenyl)ethenyl]-3-(prop-2-yn-1-yl)-2,3-dihydro-1,3,4-oxadiazol-2-one
InChI key:SFKGQKWKUGEJCM-RMKNXTFCSA-N

Molecular Formula:C14H12N2O3
Molecular Weight:256.261
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COc1ccc(\C=C\c2nn(CC#C)c(=O)o2)cc1
SMILES:COc1ccc(\C=C\c2nn(CC#C)c(=O)o2)cc1

Nrf2-ARE/hMAO-B/QR2 modulator 1, a resveratrol derivative and multi-target-directed ligand (mtdl), activated the NRF2-ARE pathway (CD = 9.83 μM), selectively inhibited hMAO-B and QR2（quinone reductase-2，NQO2) (IC 50 = 8.05 and 0.57 μM), and was able to promote hippocampal neurogenesis and exert neuroprotective and antioxidant effects in an Alzheimer's disease model.

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