Name: HEI3090
Rating: 4 (6 reviews)

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HIT ID:HIT218672710
Cas No:2377167-56-9
Common Name:HEI3090
IUPAC:(2S)-N1-(6-chloropyridin-3-yl)-N2-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidine-1,2-dicarboxamide
IUPAC:(2S)-N1-(6-chloropyridin-3-yl)-N2-[(2,4-dichlorophenyl)methyl]-5-oxopyrrolidine-1,2-dicarboxamide
InChIKey:XFDLAUDFTNZPNJ-AWEZNQCLSA-N

Molecular Formula:C18H15Cl3N4O3
Molecular Weight:441.69
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Clc1ccc(CNC(=O)[C@@H]2CCC(=O)N2C(=O)Nc2ccc(Cl)nc2)c(Cl)c1
SMILES:Clc1ccc(CNC(=O)[C@@H]2CCC(=O)N2C(=O)Nc2ccc(Cl)nc2)c(Cl)c1

HEI3090 is an activator of the P2X7R receptor. This compound enhances the production of IL-18 by stimulating dendritic cells that express P2X7R, which in turn promotes the production of IFN-γ by natural killer cells and CD4T cells within tumors, triggering a sustained anti-tumor response. Additionally, HEI3090 can be used to improve the efficacy of αPD-1 therapy in non-small cell lung cancer (NSCLC).

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