Name: (S,R,S)-VL285 Phenol-PEG4-NH2 HCl
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HIT ID:HIT218678295
Cas No:
Common Name:(S,R,S)-VL285 Phenol-PEG4-NH2 HCl
Common Name:(S,R,S)-VL285 Phenol-PEG4-NH2 HCl
alias:(S,R,S)-VL285 Phenol-PEG4-NH2 hydrochloride
alias:(S,R,S)-VL285 Phenol-PEG4-NH2 hydrochloride
IUPAC:(2S,4R)-N-({2-[(14-amino-3,6,9,12-tetraoxatetradecan-1-yl)oxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl}methyl)-4-hydroxy-1-[(2S)-3-methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoyl]pyrrolidine-2-carboxamide hydrochloride
IUPAC:(2S,4R)-N-({2-[(14-amino-3,6,9,12-tetraoxatetradecan-1-yl)oxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl}methyl)-4-hydroxy-1-[(2S)-3-methyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)butanoyl]pyrrolidine-2-carboxamide hydrochloride
InChIKey:WAOFVRRJKKKFIU-GJMJWEODSA-N

Molecular Formula:C39H54ClN5O9S
Molecular Weight:804.4
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:Cl.CC(C)[C@H](N1Cc2ccccc2C1=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1OCCOCCOCCOCCOCCN)-c1scnc1C
SMILES:Cl.CC(C)[C@H](N1Cc2ccccc2C1=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1OCCOCCOCCOCCOCCN)-c1scnc1C

(S,R,S)-VL285 Phenol-PEG4-NH2 HCl is a key component in the synthesis of molecules used in PROTAC research and targeted protein degradation. It features a (VHL)-recruiting ligand with a unique exit vector from VH032 (901490), a PEG linker, and a pendant amine for reacting with the carboxylic acid on the target ligand.

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