Name: SUN-1334H free base
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HIT ID:HIT218695325
Cas No:607737-00-8
Common Name:SUN-1334H free base
IUPAC:2-{[(2E)-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}but-2-en-1-yl]oxy}acetic acid
IUPAC:2-{[(2E)-4-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}but-2-en-1-yl]oxy}acetic acid
InChI key:PXQVDRLCSQHQTO-OWOJBTEDSA-N

Molecular Formula:C23H26F2N2O3
Molecular Weight:416.469
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:OC(=O)COC\C=C\CN1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1
SMILES:OC(=O)COC\C=C\CN1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1

SUN-1334H free base, an orally active histamine H1 receptor inhibitor, exhibits a K_i of 9.7 nM and an IC 50 of 20.3 nM. Additionally, it effectively prevents histamine-induced contractions in isolated guinea-pig ileum with an IC 50 of 0.198 μM. The compound also blocks histamine-induced bronchoconstriction and skin wheals in guinea pigs and beagle dogs, respectively, and mitigates ovalbumin-induced rhinitis in guinea pigs.

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