Name: A-77636
Rating: 4 (6 reviews)

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HIT ID:HIT218695559
Cas No:778546-51-3
Common Name:A-77636
IUPAC:(1R)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydro-1H-2-benzopyran-5,6-diol
IUPAC:(1R)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydro-1H-2-benzopyran-5,6-diol
InChI key:QLJOSZATCBCBDR-RJSSIDMBSA-N

Molecular Formula:C20H27NO3
Molecular Weight:329.44
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:NC[C@@H]1OC(Cc2c(O)c(O)ccc12)[C@@]12CC3CC(CC(C3)C1)C2
SMILES:NC[C@@H]1OC(Cc2c(O)c(O)ccc12)[C@@]12CC3CC(CC(C3)C1)C2

A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 value of 8.13. It demonstrates the highest affinity for the dopamine D1 receptor with a dissociation constant (Ki) of 39.8 nM and a pKi of 7.40 ± 0.09. Notably, A-77636 exhibits antiparkinsonian activity [1].

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