Name: Sp-8-Br-PET-cGMPS
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HIT ID:HIT218695691
Cas No:172806-21-2
Common Name:Sp-8-Br-PET-cGMPS
IUPAC:3-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxo-2-sulfanyl-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-bromo-6-phenyl-3H,4H,9H-imidazo[1,2-a]purin-9-one
IUPAC:3-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxo-2-sulfanyl-hexahydro-2lambda5-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-2-bromo-6-phenyl-3H,4H,9H-imidazo[1,2-a]purin-9-one
InChI key:DBYADRPTMRXVDJ-QJYCJHSLSA-N

Molecular Formula:C18H15BrN5O6PS
Molecular Weight:540.28
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:[H][C@@]12COP(S)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)n1c(Br)nc2c1[nH]c1nc(cn1c2=O)-c1ccccc1
SMILES:[H][C@@]12COP(S)(=O)O[C@@]1([H])[C@@H](O)[C@@H](O2)n1c(Br)nc2c1[nH]c1nc(cn1c2=O)-c1ccccc1

Sp-8-Br-PET-cGMPS is a membrane-permeable PKG activator and an inhibitor of the membrane-permeable retinal cGMP-gated ion channels (cGMP-gated ion channel). It also serves as an activator for cGMP-dependent protein kinase I α and β. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, Sp-8-Br-PET-cGMPS does not undergo metabolic side effects and exhibits stronger lipophilicity and permeability compared to Sp-8-pCPT-cGMPS. This compound is useful for investigating the role of the cGMP signaling pathway in the nervous system.

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