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HIT218696230
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HIT218696230
  • HIT ID:HIT218696230
  • Cas No:26513-90-6
  • Common Name:Letimide
  • alias:MA-1443, MA1443, MA 1443
  • IUPAC:3-[2-(diethylamino)ethyl]-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione
    IUPAC:3-[2-(diethylamino)ethyl]-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione
  • InChIKey:GRPWANKDBCDDEV-UHFFFAOYSA-N
  • Molecular Formula:C14H18N2O3
  • Molecular Weight:262.309
  • Hydrogen Bond Donor (HBD):
  • Hydrogen Bond Acceptor (HBA):
  • LogP:
  • SMILES:CCN(CC)CCn1c(=O)oc2ccccc2c1=O
    SMILES:CCN(CC)CCn1c(=O)oc2ccccc2c1=O
  • Letimide is a cyclic salicylamide derivative engineered for enhanced potency, demonstrating pharmacological activity superior to acetylsalicylic acid. In standardized assays, the compound exhibits no clastogenic activity, with micronucleus tests in murine models showing no significant increase over control groups. It is utilized in genotoxicity and cytogenetic research, particularly for evaluating sister chromatid exchange frequencies and chromosomal integrity, where it consistently shows no induction of aberrations at tested concentrations.
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