Name: Ritobegron ethyl
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HIT ID:HIT218696508
Cas No:255733-81-4
Common Name:Ritobegron ethyl
alias:Ritobegron ethyl, (-)-, KUC-7483 free base, (-)-Ritobegron ethyl
alias:Ritobegron ethyl, (-)-, KUC-7483 free base, (-)-Ritobegron ethyl
IUPAC:ethyl 2-[4-(2-{[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)-2,5-dimethylphenoxy]acetate
IUPAC:ethyl 2-[4-(2-{[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)-2,5-dimethylphenoxy]acetate
InChIKey:SLXOKVKOBXCWCK-SBUREZEXSA-N

Molecular Formula:C23H31NO5
Molecular Weight:401.503
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCOC(=O)COc1cc(C)c(CCN[C@@H](C)[C@H](O)c2ccc(O)cc2)cc1C
SMILES:CCOC(=O)COc1cc(C)c(CCN[C@@H](C)[C@H](O)c2ccc(O)cc2)cc1C

Ritobegron (also known as KUC-7483) is a potent and selective β3-adrenergic receptor agonist. In studies involving transfected human β-AR, Ritobegron exhibits significant and selective agonistic activity towards β(3)-AR. In rats, it shows high selectivity for the bladder over other organs. In anesthetized rats, Ritobegron effectively reduces bladder pressure with minimal impact on the cardiovascular system. It holds potential as a compound for treating overactive bladder.

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