Name: MRT-92
Rating: 4 (6 reviews)

In Stock

SDF File

Edit Structure

Find Similar

* 凭借在化合物合成方面的丰富经验，我们可以根据您的研究需求为该产品提供快速定制合成服务。

HIT ID:HIT218697257
Cas No:1428315-82-5
Common Name:MRT-92
IUPAC:3,4,5-trimethoxy-N-(N-{4-methyl-3-[4-(2-phenylethyl)benzamido]phenyl}carbamimidoyl)benzamide
IUPAC:3,4,5-trimethoxy-N-(N-{4-methyl-3-[4-(2-phenylethyl)benzamido]phenyl}carbamimidoyl)benzamide
InChIKey:TVUOHEUCOWBVRU-UHFFFAOYSA-N

Molecular Formula:C33H34N4O5
Molecular Weight:566.658
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1ccc(C)c(NC(=O)c2ccc(CCc3ccccc3)cc2)c1
SMILES:COc1cc(cc(OC)c1OC)C(=O)NC(=N)Nc1ccc(C)c(NC(=O)c2ccc(CCc3ccccc3)cc2)c1

MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC₅₀=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.

Marketplace OffersShowing from 1 suppliers

You cannot determine which compound library is the best fit for your project? Do you need a custom solution? AnyMol is always ready to help you.

：400-820-0310

Loading ~