Name: RWJ-58643
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HIT ID:HIT218697310
Cas No:287183-00-0
Common Name:RWJ-58643
IUPAC:(2S,4R)-1-acetyl-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide
IUPAC:(2S,4R)-1-acetyl-N-[1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1-oxopentan-2-yl]-4-hydroxypyrrolidine-2-carboxamide
InChIKey:VXDAVYUFYPFGDX-ATFAPYMMSA-N

Molecular Formula:C20H26N6O4S
Molecular Weight:446.53
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CC(=O)N1C[C@H](O)C[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)c1nc2ccccc2s1
SMILES:CC(=O)N1C[C@H](O)C[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)c1nc2ccccc2s1

RWJ-58643 is a β-trypsin and trypsin inhibitor used in studies to inhibit allergic inflammatory conditions. The compound was effective in reducing nasal allergy symptoms, eosinophil infiltration, and interleukin-5 (IL-5) levels at a lower dose (100 mg). However, at higher doses (300 mg and 600 mg), an increase in eosinophils and elevated IL-5 levels were observed, showing a clear dose-dependent response.

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