Name: pep2-SVKI
Rating: 5 (10 reviews)

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HIT ID:HIT218698021
Cas No:328944-75-8
常用名:pep2-SVKI
IUPAC:(2S,3S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-carbamoylpropanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]acetamido}-3-methylpentanamido]-4-carboxybutanamido]-3-hydroxypropanamido]-3-methylbutanamido]hexanamido]-3-methylpentanoic acid
IUPAC:(2S,3S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S,3S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-carbamoylpropanamido]-3-methylbutanamido]-3-(4-hydroxyphenyl)propanamido]acetamido}-3-methylpentanamido]-4-carboxybutanamido]-3-hydroxypropanamido]-3-methylbutanamido]hexanamido]-3-methylpentanoic acid
InChI key:YWTNLHXVGSIPEM-YDSVATBTSA-N

分子式:C60H93N13O18
分子量:1284.477
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)[C@@H](C)CC)C(C)C)C(O)=O
SMILES:CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)[C@@H](C)CC)C(C)C)C(O)=O

Inhibitor peptide corresponding to last 10 amino acids of the C-terminus of the GluA2 AMPA receptor subunit. Disrupts binding of GluA2 (at the C-terminal PDZ site) with glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP) and protein interacting with C kinase (PICK1). Increases amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD).

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