Name: Ceftolozane
Rating: 5 (10 reviews)

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结构编辑

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HIT ID:HIT218700724
Cas No:689293-68-3
常用名:Ceftolozane
IUPAC:5-amino-2-{[(6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium
IUPAC:5-amino-2-{[(6R,7R)-7-[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-4-{[(2-aminoethyl)carbamoyl]amino}-1-methyl-1H-pyrazol-2-ium
InChI key:JHFNIHVVXRKLEF-DCZLAGFPSA-O

分子式:C23H31N12O8S2
分子量:667.7
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12SCC(C[n+]3cc(NC(=O)NCCN)c(N)n3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C(O)=O)\c1nsc(N)n1)C(O)=O
SMILES:[H][C@]12SCC(C[n+]3cc(NC(=O)NCCN)c(N)n3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C(O)=O)\c1nsc(N)n1)C(O)=O

Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics unless this enzyme is inhibited. .

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