Name: ARV-393
Rating: 4 (6 reviews)

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HIT ID:HIT218700921
Cas No:2851885-95-3
Common Name:ARV-393
alias:ARV393
IUPAC:2-({6-[(5-chloro-2-{4-[(1r,3r)-3-{4-[2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-2,3-dihydro-1H-isoindol-5-yl]piperidin-1-yl}cyclobutoxy]piperidin-1-yl}pyrimidin-4-yl)amino]-2-oxo-1-(propan-2-yl)-1,2-dihydroquinolin-3-yl}oxy)-N-methylacetamide
IUPAC:2-({6-[(5-chloro-2-{4-[(1r,3r)-3-{4-[2-(2,6-dioxopiperidin-3-yl)-4-fluoro-1-oxo-2,3-dihydro-1H-isoindol-5-yl]piperidin-1-yl}cyclobutoxy]piperidin-1-yl}pyrimidin-4-yl)amino]-2-oxo-1-(propan-2-yl)-1,2-dihydroquinolin-3-yl}oxy)-N-methylacetamide
InChI key:ZOGOEUHUEFKKTD-VVDHFOCHSA-N

Molecular Formula:C46H53ClFN9O7
Molecular Weight:898.43
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)O[C@H]3C[C@@H](C3)N3CCC(CC3)c3ccc4C(=O)N(Cc4c3F)C3CCC(=O)NC3=O)ccc2n(C(C)C)c1=O
SMILES:CNC(=O)COc1cc2cc(Nc3nc(ncc3Cl)N3CCC(CC3)O[C@H]3C[C@@H](C3)N3CCC(CC3)c3ccc4C(=O)N(Cc4c3F)C3CCC(=O)NC3=O)ccc2n(C(C)C)c1=O

ARV-393 is a PROTAC degrader targeting BCL6 with the advantage of being highly potent and orally available.ARV-393 recruits BCL6 and E3 ligase cerebellum to rapidly degrade BCL6 through the cell's natural ubiquitin proteasome system for the treatment of diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL).

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