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- HIT ID:HIT218723658
- Cas No:
- 常用名:5α-Androstan-3β-ol
- 别名:NSC 50887
- InChI key:DJTOLSNIKJIDFF-UHFFFAOYSA-N
- 分子式:C19H32O
- 分子量:276.464
- 氢键供体数 (HBD):1
- 氢键受体数 (HBA):1
- LogP:7.41
- 5α-Androstan-3β-ol, a steroidal androgen, demonstrates selective interaction with cellular components, showing affinity for the androgen receptor (AR) with an IC50 of 1.7 µM and activating the pregnane X receptor (PXR) in HepG2 cells with an EC50 of 0.8 µM. It selectively inhibits the hydroxylase activities of 16α- and 6β-hydroxylase over 16β- or 7α-hydroxylase, with IC50 values of 70 and 110 µM, compared to >150 µM for the latter enzymes, indicating a specificity in its enzyme inhibition profile. Additionally, administration of this compound at a dosage of 30 mg/kg results in a decrease in testis weight and sperm production in mice, highlighting its biological effects on male reproductive parameters.
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