Name: cis-NVP-ADW742
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT218801700
Cas No:475489-15-7
常用名:cis-NVP-ADW742
IUPAC:5-[3-(benzyloxy)phenyl]-7-[(1s,3s)-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
IUPAC:5-[3-(benzyloxy)phenyl]-7-[(1s,3s)-3-[(pyrrolidin-1-yl)methyl]cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
InChI key:LSFLAQVDISHMNB-DKXQDJALSA-N

分子式:C28H31N5O
分子量:453.59
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCC2)C1
SMILES:Nc1ncnc2n(cc(-c3cccc(OCc4ccccc4)c3)c12)[C@@H]1C[C@H](CN2CCCC2)C1

NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.

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