Name: Sonrotoclax
Rating: 4 (6 reviews)

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HIT ID:HIT218801731
Cas No:2383086-06-2
Common Name:Sonrotoclax
alias:BGB 11417
IUPAC:N-[3-nitro-4-({[(1r,4r)-4-hydroxy-4-methylcyclohexyl]methyl}amino)benzenesulfonyl]-4-{2-[(2S)-2-[2-(propan-2-yl)phenyl]pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl}-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide
IUPAC:N-[3-nitro-4-({[(1r,4r)-4-hydroxy-4-methylcyclohexyl]methyl}amino)benzenesulfonyl]-4-{2-[(2S)-2-[2-(propan-2-yl)phenyl]pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl}-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide
InChIKey:ZQTKOYMWCCSKON-XKXNWSITSA-N

Molecular Formula:C49H59N7O7S
Molecular Weight:890.11
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CC(C)c1ccccc1[C@@H]1CCCN1C1CC2(C1)CCN(CC2)c1ccc(C(=O)NS(=O)(=O)c2ccc(NC[C@H]3CC[C@](C)(O)CC3)c(c2)[N+]([O-])=O)c(Oc2cnc3[nH]ccc3c2)c1
SMILES:CC(C)c1ccccc1[C@@H]1CCCN1C1CC2(C1)CCN(CC2)c1ccc(C(=O)NS(=O)(=O)c2ccc(NC[C@H]3CC[C@](C)(O)CC3)c(c2)[N+]([O-])=O)c(Oc2cnc3[nH]ccc3c2)c1

Sonrotoclax is a potent, orally active inhibitor of Bcl2, demonstrating effective cell-killing activity against a range of lymphoma and leukemia cell lines ^[1].

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