Name: YS-67
Rating: 4 (6 reviews)

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HIT ID:HIT218801732
Cas No:2761327-15-3
Common Name:YS-67
IUPAC:4-(1-ethyl-2-phenyl-1H-indol-3-yl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazoline
IUPAC:4-(1-ethyl-2-phenyl-1H-indol-3-yl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazoline
InChI key:LZGZDXBHZFWXID-UHFFFAOYSA-N

Molecular Formula:C32H34N4O3
Molecular Weight:522.649
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCn1c(c(-c2ncnc3cc(OC)c(OCCCN4CCOCC4)cc23)c2ccccc12)-c1ccccc1
SMILES:CCn1c(c(-c2ncnc3cc(OC)c(OCCCN4CCOCC4)cc23)c2ccccc12)-c1ccccc1

YS-67 is an orally available, selective and potent EGFR inhibitor with antitumor activity, inhibits p-EGFR and p-AKT, and inhibits the proliferation of A549, PC-9, and A431 cells.YS-67 blocks cell cycle progression and induces apoptosis in the G0/G1 phase, and can be used in the study of non-small-cell lung cancer.

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