Name: BTM-3528
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HIT ID:HIT218832559
Cas No:2054998-45-5
Common Name:BTM-3528
alias:BTM3528, BTM 3528
IUPAC:4-(3-fluorophenyl)-3-methyl-1-[5-(propan-2-ylsulfanyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-1H-pyrazole-5-carboxylic acid
IUPAC:4-(3-fluorophenyl)-3-methyl-1-[5-(propan-2-ylsulfanyl)-4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-1H-pyrazole-5-carboxylic acid
InChI key:CSKLESTWCMVVHO-UHFFFAOYSA-N

Molecular Formula:C24H19F4N3O2S2
Molecular Weight:521.55
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CC(C)Sc1sc(nc1-c1ccc(cc1)C(F)(F)F)-n1nc(C)c(c1C(O)=O)-c1cccc(F)c1
SMILES:CC(C)Sc1sc(nc1-c1ccc(cc1)C(F)(F)F)-n1nc(C)c(c1C(O)=O)-c1cccc(F)c1

BTM-3528 is an activator of the mitochondrial protease OMA1 with anticancer activity.BTM-3528 activates the ISR via the mitochondrial protease OMA1, inducing OMA1-dependent cleavage of DELE1 and OPA1 and mitochondrial fragmentation.BTM-3528 induces cell growth arrest and apoptosis.

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