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  3. HIT218832564
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HIT218832564
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HIT218832564
  • HIT ID:HIT218832564
  • Cas No:
  • 常用名:Harzianopyridone
  • 别名:(-)-Harzianopyridone
  • IUPAC:4-hydroxy-5,6-dimethoxy-3-(2-methylhex-4-enoyl)-1,2-dihydropyridin-2-one
    IUPAC:4-hydroxy-5,6-dimethoxy-3-(2-methylhex-4-enoyl)-1,2-dihydropyridin-2-one
  • InChI key:FPYAYFJAGDIMEX-UHFFFAOYSA-N
  • 分子式:C14H19NO5
  • 分子量:281.308
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1[nH]c(=O)c(C(=O)C(C)CC=CC)c(O)c1OC
    SMILES:COc1[nH]c(=O)c(C(=O)C(C)CC=CC)c(O)c1OC
  • Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 3,570.00
    1

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