Name: Harzianopyridone
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HIT ID:HIT218832564
Cas No:
Common Name:Harzianopyridone
alias:(-)-Harzianopyridone
IUPAC:4-hydroxy-5,6-dimethoxy-3-(2-methylhex-4-enoyl)-1,2-dihydropyridin-2-one
IUPAC:4-hydroxy-5,6-dimethoxy-3-(2-methylhex-4-enoyl)-1,2-dihydropyridin-2-one
InChIKey:FPYAYFJAGDIMEX-UHFFFAOYSA-N

Molecular Formula:C14H19NO5
Molecular Weight:281.308
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COc1[nH]c(=O)c(C(=O)C(C)CC=CC)c(O)c1OC
SMILES:COc1[nH]c(=O)c(C(=O)C(C)CC=CC)c(O)c1OC

Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC₅₀ values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC₅₀ value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC₅₀ values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC₅₀ values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.

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