Name: 8,12-iso-iPF2α-VI
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HIT ID:HIT218832571
Cas No:
Common Name:8,12-iso-iPF2α-VI
alias:8,12-iso-Isoprostane-F2α-VI, 12-iso-5,6E,14Z-Prostaglandin F2α, 12-iso-5,6E,14Z-PGF2α
alias:8,12-iso-Isoprostane-F2α-VI, 12-iso-5,6E,14Z-Prostaglandin F2α, 12-iso-5,6E,14Z-PGF2α
IUPAC:7-[3,5-dihydroxy-2-(oct-2-en-1-yl)cyclopentyl]-5-hydroxyhept-6-enoic acid
IUPAC:7-[3,5-dihydroxy-2-(oct-2-en-1-yl)cyclopentyl]-5-hydroxyhept-6-enoic acid
InChIKey:RZCPXIZGLPAGEV-UHFFFAOYSA-N

Molecular Formula:C20H34O5
Molecular Weight:354.487
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCC=CCC1C(O)CC(O)C1C=CC(O)CCCC(O)=O
SMILES:CCCCCC=CCC1C(O)CC(O)C1C=CC(O)CCCC(O)=O

8,12-iso-iPF2α-VI, an isoprostane, arises from non-enzymatic, free radical-induced peroxidation of membrane lipids. It is the predominant isoprostane formed during lipid peroxidation and serves as a biomarker for oxidative stress. Detectable in hepatic tissue post CCl4-induced oxidative damage, 8,12-iso-iPF2α-VI levels are also elevated in the urine, blood, and cerebrospinal fluid of Alzheimer's disease patients.

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