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HIT218832575
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HIT218832575
  • HIT ID:HIT218832575
  • Cas No:
  • 常用名:Nε-(1-Carboxymethyl)-L-lysine
  • 别名:CML
  • IUPAC:2-amino-6-[(carboxymethyl)amino]hexanoic acid
    IUPAC:2-amino-6-[(carboxymethyl)amino]hexanoic acid
  • InChI key:NUXSIDPKKIEIMI-UHFFFAOYSA-N
  • 分子式:C8H16N2O4
  • 分子量:204.226
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:NC(CCCCNCC(O)=O)C(O)=O
    SMILES:NC(CCCCNCC(O)=O)C(O)=O
  • Nε-(1-Carboxymethyl)-L-lysine (CML), an advanced glycation end product (AGE), is formed through the oxidative modification of glycated proteins under conditions of oxidative stress.1,2,3 Its levels escalate with age, diabetes, cancer, vascular diseases, and various pathologies associated with oxidative stress.1,4,5 CML interacts with the membrane-bound receptor for AGEs (RAGE), initiating signaling via MAPKs and NF-κB pathways. Conversely, a truncated version of RAGE generates a soluble protein that sequesters CML, thereby diminishing this signaling.6,7
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 915.00
    1

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