Name: 17(R)-Resolvin D1 methyl ester
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HIT ID:HIT218832577
Cas No:
Common Name:17(R)-Resolvin D1 methyl ester
alias:Aspirin-triggered-Resolvin D1 methyl ester
alias:Aspirin-triggered-Resolvin D1 methyl ester
IUPAC:methyl 7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoate
IUPAC:methyl 7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoate
InChIKey:WUKVAFWBFGABJN-UHFFFAOYSA-N

Molecular Formula:C23H34O5
Molecular Weight:390.52
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCC=CCC(O)C=CC=CC=CC=CC(O)C(O)CC=CCCC(=O)OC
SMILES:CCC=CCC(O)C=CC=CC=CC=CC(O)C(O)CC=CCCC(=O)OC

17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that equivalently inhibits human polymorphonuclear leukocyte migration across the endothelium (EC₅₀= ~30 nM), a precursor to acute inflammation. Unlike RvD1, it resists rapid degradation by eicosanoid oxidoreductases. In a mouse peritonitis model, 17(R)-RvD1 dose-dependently reduces leukocyte infiltration, achieving up to a 35% decrease with a 100 ng dose. Additionally, its methyl ester derivative, designed to enhance its pharmacokinetic and distribution properties as a more lipophilic prodrug, can be converted back into the active acid form by intracellular esterases.

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