Name: Tafluprost ethyl ester
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HIT ID:HIT218832581
Cas No:
Common Name:Tafluprost ethyl ester
alias:AFP 175
IUPAC:ethyl 7-[2-(3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl]hept-5-enoate
IUPAC:ethyl 7-[2-(3,3-difluoro-4-phenoxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl]hept-5-enoate
InChI key:SPWJIEVPQKMQPO-UHFFFAOYSA-N

Molecular Formula:C24H32F2O5
Molecular Weight:438.512
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCOC(=O)CCCC=CCC1C(O)CC(O)C1C=CC(F)(F)COc1ccccc1
SMILES:CCOC(=O)CCCC=CCC1C(O)CC(O)C1C=CC(F)(F)COc1ccccc1

Tafluprost, an analog of prostaglandin F2α (PGF2α) that primarily targets the FP receptor, is employed in glaucoma treatment. Tafluprost (free acid) serves as a potent FP receptor agonist with a Ki value of 0.4 nM. Its derivative, tafluprost ethyl ester, potentially offers enhanced lipid solubility relative to its free acid form, possibly leading to superior tissue absorption and reduced effective concentration requirements.

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