Name: (±)11(12)-EpETE
Rating: 5 (10 reviews)

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HIT ID:HIT218832591
Cas No:
常用名:(±)11(12)-EpETE
别名:(±)11,12-EEQ
IUPAC:10-[3-(octa-2,5-dien-1-yl)oxiran-2-yl]deca-5,8-dienoic acid
IUPAC:10-[3-(octa-2,5-dien-1-yl)oxiran-2-yl]deca-5,8-dienoic acid
InChI key:QHOKDYBJJBDJGY-UHFFFAOYSA-N

分子式:C20H30O3
分子量:318.457
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCC=CCC=CCC1OC1CC=CCC=CCCCC(O)=O
SMILES:CCC=CCC=CCC1OC1CC=CCC=CCCCC(O)=O

Eicosapentaenoic acid (EPA) is metabolized into epoxyeicosatetraenoic acids (EpETE) by multiple cytochrome P450 isoforms. The predominant compound of this epoxygenase pathway, (±)17(18)-EpETE, induces relaxation in vascular and airway smooth muscles through its action on large conductance Ca2+-activated K+ (BKCa) channels, specifically by binding to the BKα channel subunits. Another notable epoxygenase pathway derivative, (±)11(12)-EpETE, also generated from EPA via CYP450 activity in both in vitro and in vivo studies, has biological and physiological roles that are yet to be fully elucidated.

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