Name: 17β-Hydroxywortmannin
Rating: 4 (6 reviews)

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HIT ID:HIT218832593
Cas No:
Common Name:17β-Hydroxywortmannin
alias:Wortmannin-17β-ol
IUPAC:6-hydroxy-18-(methoxymethyl)-1,5-dimethyl-11,16-dioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate
IUPAC:6-hydroxy-18-(methoxymethyl)-1,5-dimethyl-11,16-dioxo-13,17-dioxapentacyclo[10.6.1.0^{2,10}.0^{5,9}.0^{15,19}]nonadeca-2(10),12(19),14-trien-3-yl acetate
InChIKey:XLJORQYAOTYVQS-UHFFFAOYSA-N

Molecular Formula:C23H26O8
Molecular Weight:430.453
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:COCC1OC(=O)c2coc3c2C1(C)C1=C(C2CCC(O)C2(C)CC1OC(C)=O)C3=O
SMILES:COCC1OC(=O)c2coc3c2C1(C)C1=C(C2CCC(O)C2(C)CC1OC(C)=O)C3=O

17β-Hydroxywortmannin is an orally active phosphatidylinositol-3-kinase (PI-3-kinase) inhibitor, exhibiting an IC₅₀ of 0.5 nM and notably suppresses osteoclast resorption at an IC₅₀ of 10 nM. Additionally, it demonstrates antitumor activity.

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