Name: 14,15-Leukotriene C4
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HIT ID:HIT218832595
Cas No:
Common Name:14,15-Leukotriene C4
alias:Eoxin C4
IUPAC:14-{[2-(4-amino-4-carboxybutanamido)-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-15-hydroxyicosa-5,8,10,12-tetraenoic acid
IUPAC:14-{[2-(4-amino-4-carboxybutanamido)-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-15-hydroxyicosa-5,8,10,12-tetraenoic acid
InChI key:OBQVBASHEWLKCQ-UHFFFAOYSA-N

Molecular Formula:C30H47N3O9S
Molecular Weight:625.78
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCCCCC(O)C(SCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C=CC=CC=CCC=CCCCC(O)=O
SMILES:CCCCCC(O)C(SCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C=CC=CC=CCC=CCCCC(O)=O

Leukotriene C4 (14,15-LTC4) is an inflammatory mediator synthesized from arachidonic acid through the actions of 15- and 12-lipoxygenases (LOs), involving intermediates such as 15-HpETE and 14,15-LTA4. Unlike the majority of leukotrienes formed via the 5-LO pathway, 14,15-LTC4 is an eoxin predominantly produced by eosinophils, although mast cells and nasal polyps can also synthesize it. While its physiological roles are not well understood, 14,15-LTC4 exhibits limited contractile activity on guinea pig ileum and pulmonary parenchyma. However, it can increase vascular permeability in human endothelial cell monolayers in vitro with potency comparable to 5-LO-derived leukotrienes, contributing to plasma leakage characteristic of inflammation.

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