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  3. HIT218832595
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HIT218832595
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HIT218832595
  • HIT ID:HIT218832595
  • Cas No:
  • 常用名:14,15-Leukotriene C4
  • 别名:Eoxin C4
  • IUPAC:14-{[2-(4-amino-4-carboxybutanamido)-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-15-hydroxyicosa-5,8,10,12-tetraenoic acid
    IUPAC:14-{[2-(4-amino-4-carboxybutanamido)-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-15-hydroxyicosa-5,8,10,12-tetraenoic acid
  • InChI key:OBQVBASHEWLKCQ-UHFFFAOYSA-N
  • 分子式:C30H47N3O9S
  • 分子量:625.78
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCCC(O)C(SCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C=CC=CC=CCC=CCCCC(O)=O
    SMILES:CCCCCC(O)C(SCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C=CC=CC=CCC=CCCCC(O)=O
  • Leukotriene C4 (14,15-LTC4) is an inflammatory mediator synthesized from arachidonic acid through the actions of 15- and 12-lipoxygenases (LOs), involving intermediates such as 15-HpETE and 14,15-LTA4. Unlike the majority of leukotrienes formed via the 5-LO pathway, 14,15-LTC4 is an eoxin predominantly produced by eosinophils, although mast cells and nasal polyps can also synthesize it. While its physiological roles are not well understood, 14,15-LTC4 exhibits limited contractile activity on guinea pig ileum and pulmonary parenchyma. However, it can increase vascular permeability in human endothelial cell monolayers in vitro with potency comparable to 5-LO-derived leukotrienes, contributing to plasma leakage characteristic of inflammation.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 2,090.00
    1

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