Name: 5(S)-HEPE
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HIT ID:HIT218832606
Cas No:
Common Name:5(S)-HEPE
IUPAC:5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
IUPAC:5-hydroxyicosa-6,8,11,14,17-pentaenoic acid
InChIKey:FTAGQROYQYQRHF-UHFFFAOYSA-N

Molecular Formula:C20H30O3
Molecular Weight:318.457
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCC=CCC=CCC=CCC=CC=CC(O)CCCC(O)=O
SMILES:CCC=CCC=CCC=CCC=CC=CC(O)CCCC(O)=O

5(S)-HEPE, an active metabolite of eicosapentaenoic acid (EPA), is produced via the action of 5-lipoxygenase (5-LO). This compound functions as an agonist for G protein-coupled receptor 119 (GPR119), promoting cAMP accumulation in CHO-K1 cells expressing human GPR119 at 10 µM concentration. Additionally, 5(S)-HEPE enhances glucose-stimulated insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells at the same concentration. Notably, serum levels of 5(S)-HEPE are increased in hyperlipidemia patients.

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