Name: U-51605
Rating: 5 (10 reviews)

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HIT ID:HIT218832624
Cas No:
常用名:U-51605
IUPAC:7-[6-(oct-1-en-1-yl)-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl]hept-5-enoic acid
IUPAC:7-[6-(oct-1-en-1-yl)-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl]hept-5-enoic acid
InChI key:SRIZDZJPKIYUPZ-UHFFFAOYSA-N

分子式:C20H32N2O2
分子量:332.488
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCC=CC1C(CC=CCCCC(O)=O)C2CC1N=N2
SMILES:CCCCCCC=CC1C(CC=CCCCC(O)=O)C2CC1N=N2

U-51605, a stable analog of the endoperoxide prostaglandin H2 (PGH2), functions as an inhibitor with greater selectivity towards prostacyclin (PGI) synthase over thromboxane (TX) synthase. It also acts as a partial agonist at TP receptors. Studies show that at a concentration of 2.8 µM, U-51605 effectively inhibits PGI synthase in human foreskin fibroblasts, while a concentration of 5.6 µM is required to inhibit human platelet TX synthase. Furthermore, U-51605, at up to 1 µM, decreases the release of prostacyclin in SHR aorta triggered by the calcium ionophore A-23187 without impacting TXA2 production, and notably enhances the release of PGE2 and PGF2α.

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