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  3. HIT218832626
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HIT218832626
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HIT218832626
  • HIT ID:HIT218832626
  • Cas No:
  • 常用名:11β-13,14-dihydro-15-keto Prostaglandin F2α
    常用名:11β-13,14-dihydro-15-keto Prostaglandin F2α
  • 别名:11β-13,14-dihydro-15-keto PGF2α
  • IUPAC:7-[3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid
    IUPAC:7-[3,5-dihydroxy-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid
  • InChI key:VKTIONYPMSCHQI-UHFFFAOYSA-N
  • 分子式:C20H34O5
  • 分子量:354.487
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCCC(=O)CCC1C(O)CC(O)C1CC=CCCCC(O)=O
    SMILES:CCCCCC(=O)CCC1C(O)CC(O)C1CC=CCCCC(O)=O
  • 11β-13,14-Dihydro-15-keto PGF2α, a PGD2 metabolite in the 15-hydroxy PGDH pathway, is formed in human males upon infusion or inhalation of tritiated PGD2, with peak plasma levels of both 11β-PGF2α and 11β-13,14-dihydro-15-keto PGF2α observed within 10 minutes. In human lung homogenates, PGD2 is metabolized firstly to 11β-PGF2α and subsequently to 11β-15-keto-PGF2α in the presence of NAD+, but not to 11β-13,14-dihydro-15-keto PGF2α. Conversely, guinea pig liver and kidney homogenates can metabolize PGD2 to 11β-13,14-dihydro-15-keto PGF2α via 11β-PGF2α, with both NAD+ and NADP+ being requisite for this conversion.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
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    ¥ 945.00
    1

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