Name: 2,3-dinor-8-iso Prostaglandin F2α
Rating: 5 (10 reviews)

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HIT ID:HIT218832633
Cas No:
常用名:2,3-dinor-8-iso Prostaglandin F2α
常用名:2,3-dinor-8-iso Prostaglandin F2α
别名:2,3-dinor-iPF2α-III
IUPAC:5-[3,5-dihydroxy-2-(3-hydroxyoct-1-en-1-yl)cyclopentyl]pent-3-enoic acid
IUPAC:5-[3,5-dihydroxy-2-(3-hydroxyoct-1-en-1-yl)cyclopentyl]pent-3-enoic acid
InChI key:IDKLJIUIJUVJNR-UHFFFAOYSA-N

分子式:C18H30O5
分子量:326.433
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC(O)C=CC1C(O)CC(O)C1CC=CCC(O)=O
SMILES:CCCCCC(O)C=CC1C(O)CC(O)C1CC=CCC(O)=O

8-isoProstaglandin F2α (8-isoPGF2α; 8-isoprostane) is a byproduct of non-specific lipid peroxidation, resembling prostaglandin in structure. In humans and rats, its metabolite, 12,3-dinor-8-isoPGF2α, is formed following exogenous administration of 8-isoPGF2α, which is converted to 2,3-dinor-8-isoPGF1α and 2,3-dinor-8-isoPGF2α. Additionally, rat hepatocytes can further break down 8-isoPGF2α into a β-oxidation product, 2,3,4,5-tetranor-8-isoPGF2α. The metabolite, 2,3-dinor-8-isoPGF2α, is normally found in human urine at concentrations of 200-300 pg/ml. Its levels rise in conditions associated with oxidative stress, such as smoking, demonstrating a correlation with the concentration of its precursor, 8-isoPGF2α.

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