Name: 11-keto Fluprostenol
Rating: 5 (10 reviews)

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HIT ID:HIT218832640
Cas No:
常用名:11-keto Fluprostenol
别名:Fluprostenol Prostaglandin D2
IUPAC:7-(5-hydroxy-2-{3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}-3-oxocyclopentyl)hept-5-enoic acid
IUPAC:7-(5-hydroxy-2-{3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}-3-oxocyclopentyl)hept-5-enoic acid
InChI key:MDMHJAKZGBRYTF-UHFFFAOYSA-N

分子式:C23H27F3O6
分子量:456.458
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(COc1cccc(c1)C(F)(F)F)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O
SMILES:OC(COc1cccc(c1)C(F)(F)F)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O

11-Keto Fluprostenol, a potent analog of prostaglandin F2α (PGF2α), primarily interacts with the FP receptor. It is a structurally modified derivative of prostaglandin D2 (PGD2) designed to enhance its potency and extend its half-life. The compound is produced by oxidizing fluprostenol at the C-11 position, which results in 11-keto fluprostenol. This modification allows 11-keto Fluprostenol to exhibit moderate affinity for the CRTH2/DP2 receptor, though it shows negligible activity at the DP1 receptor, distinguishing its action from that of PGD2.

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