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- HIT ID:HIT218832649
- Cas No:
- 常用名:(±)9(10)-DiHOME
- 别名:Leukotoxin diol
- InChI key:XEBKSQSGNGRGDW-UHFFFAOYSA-N
- 分子式:C18H34O4
- 分子量:314.466
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- (±)9(10)-DiHOME, the diol derivative of (±)9(10)-EpOME—a cytochrome P450-derived epoxide of linoleic acid also known as leukotoxin—is formed through the action of soluble epoxide hydrolase (sEH) in neutrophils. It exhibits toxicity towards Sf21 cells expressing sEH as well as tolacZ-expressing control cells, differing from leukotoxin which only harms sEH-containing cells. Furthermore, combined exposure to 9(10)- and 12(13)-DiHOME leads to cell death in rabbit renal proximal tubule cells by disrupting mitochondrial respiration, and causes lung injury, respiratory distress, and mortality in mice, highlighting its role as a toxic lipid mediator. Specifically, 9(10)-DiHOME has been associated with acute respiratory distress syndrome (ARDS), a severe and often deadly complication in patients with major burns. Elevated levels of this compound have been detected in the bronchoalveolar lavage fluid (BALF) of women, but not men, with chronic obstructive pulmonary disease (COPD), and its levels are also increased in patients with allergic asthma, indicating its significance in respiratory conditions.
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- 供应商TargetMol规格货期8-10周纯度-待询1
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