Name: 15-deoxy-Δ12,14-Prostaglandin D2
Rating: 5 (10 reviews)

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HIT ID:HIT218832656
Cas No:
常用名:15-deoxy-Δ12,14-Prostaglandin D2
常用名:15-deoxy-Δ12,14-Prostaglandin D2
别名:15-deoxy-Δ12,14-PGD2
IUPAC:7-[5-hydroxy-2-(oct-2-en-1-ylidene)-3-oxocyclopentyl]hept-5-enoic acid
IUPAC:7-[5-hydroxy-2-(oct-2-en-1-ylidene)-3-oxocyclopentyl]hept-5-enoic acid
InChI key:QUGBPWLPAUHDTI-UHFFFAOYSA-N

分子式:C20H30O4
分子量:334.456
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC=CC=C1C(CC=CCCCC(O)=O)C(O)CC1=O
SMILES:CCCCCC=CC=C1C(CC=CCCCC(O)=O)C(O)CC1=O

15-deoxy-Δ12,14-Prostaglandin D2 (15-deoxy-Δ12,14-PGD2) is a PGD2 metabolite functioning as an agonist for the PGD2 receptor 2 (DP2), with a binding affinity (Ki) of 50 nM for the mouse DP2 receptor expressed in HEK293 cell membranes. It activates eosinophils with an EC50 of 8 nM and enhances the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), initiating PPARγ-mediated transcription at 5 µM concentration. Furthermore, it exhibits cytotoxicity towards L1210 murine leukemia cells with an IC50 of 0.3 µg/ml and displays weaker inhibition of ADP-induced platelet aggregation than PGD2, with an IC50 of 320 ng/ml.

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