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  3. HIT218832662
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HIT218832662
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HIT218832662
  • HIT ID:HIT218832662
  • Cas No:
  • 常用名:20-ethyl Prostaglandin E2
  • 别名:20-ethyl PGE2
  • IUPAC:7-[3-hydroxy-2-(3-hydroxydec-1-en-1-yl)-5-oxocyclopentyl]hept-5-enoic acid
    IUPAC:7-[3-hydroxy-2-(3-hydroxydec-1-en-1-yl)-5-oxocyclopentyl]hept-5-enoic acid
  • InChI key:NXMMZTNQIJBMBC-UHFFFAOYSA-N
  • 分子式:C22H36O5
  • 分子量:380.525
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O
    SMILES:CCCCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O
  • 20-Ethyl Prostaglandin E2 (20-ethyl PGE2) is an analog of Prostaglandin E2 (PGE2) characterized by an extended ω-chain due to two additional methylene carbon atoms. Compared to unoprostone, a clinically approved glaucoma medication and the only extensively studied prostaglandin analog sharing this structural modification, 20-ethyl PGE2 maintains the natural 15(S) allylic hydroxyl in its lower side chain, potentially enhancing its effectiveness. Unoprostone, despite being an F-series prostaglandin, exhibits reduced affinity for FP receptors because of its lower side chain modifications (13,14-dihydro-15-keto), which diminishes its medicinal potency. Notably, 20-ethyl PGE2's efficacy relative to unoprostone and its interaction with EP or other prostanoid receptors remains unconfirmed due to the lack of published ligand binding assays. E-type prostaglandins, including 20-ethyl PGE2, are broadly acknowledged for their inflammatory, cytoprotective, and diverse biological activities.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,060.00
    1

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