Name: 17-phenyl trinor Prostaglandin F2α diethyl amide
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HIT ID:HIT218832663
Cas No:
Common Name:17-phenyl trinor Prostaglandin F2α diethyl amide
Common Name:17-phenyl trinor Prostaglandin F2α diethyl amide
alias:Bimatoprost diethyl amide
IUPAC:7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl]-N,N-diethylhept-5-enamide
IUPAC:7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl]-N,N-diethylhept-5-enamide
InChI key:CDQCYBXRNLOTSU-UHFFFAOYSA-N

Molecular Formula:C27H41NO4
Molecular Weight:443.628
Hydrogen Bond Donor (HBD):
Hydrogen Bond Acceptor (HBA):
LogP:
SMILES:CCN(CC)C(=O)CCCC=CCC1C(O)CC(O)C1C=CC(O)CCc1ccccc1
SMILES:CCN(CC)C(=O)CCCC=CCC1C(O)CC(O)C1C=CC(O)CCc1ccccc1

17-Phenyl trinor Prostaglandin F2αdiethyl amide (17-phenyl trinor PGF2αdiethyl amide) is a Prostaglandin F2α(PGF2α) analog characterized by the substitution of the C-1 carboxyl group with an N-diethyl amide. Prostaglandin (PG) esters and N-ethyl amides have demonstrated ocular hypotensive properties, with N-ethyl amides introduced as alternative options for PG hypotensive prodrugs. Studies indicate that both bovine and human corneal tissues can convert N-ethyl amides of various PGs into their free acid forms at a rate of approximately 2.5 µg/g corneal tissue/hr. However, dialkyl amides like 17-phenyl trinor PGF2αdiethyl amide resist conversion by corneal amidase, showing no detectable transformation into free acids. This characteristic suggests their potential as valuable investigative tools for assessing the intrinsic intraocular hypotensive activities of PG amides.

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