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  3. HIT218832667
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HIT218832667
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HIT218832667
  • HIT ID:HIT218832667
  • Cas No:
  • 常用名:Lentztrehalose A
  • 别名:(+)-Lentztrehalose A
  • IUPAC:2-{[5-(2,3-dihydroxy-3-methylbutoxy)-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    IUPAC:2-{[5-(2,3-dihydroxy-3-methylbutoxy)-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
  • InChI key:JQXMCRHNXBMTMR-UHFFFAOYSA-N
  • 分子式:C17H32O13
  • 分子量:444.43
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CC(C)(O)C(O)COC1C(CO)OC(OC2OC(CO)C(O)C(O)C2O)C(O)C1O
    SMILES:CC(C)(O)C(O)COC1C(CO)OC(OC2OC(CO)C(O)C(O)C2O)C(O)C1O
  • Lentztrehalose A, a disaccharide microbial metabolite identified in Lentzea, exhibits a range of biological activities. This compound specifically inhibits M. smegmatis trehalase—an enzyme involved in trehalose metabolism—more effectively than trehalase from porcine kidney, with IC50 values of 0.67 mM and >20 mM, respectively. Additionally, Lentztrehalose A at a concentration of 100 mM promotes autophagy in MeWo melanoma and OVK18 ovarian cancer cells. When administered at 50 mg/kg daily, it enhances survival rates and impedes tumor growth in a Sarcoma 180 murine sarcoma model.
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